The GI-MAP is the most thorough stool test on the market. In PKU, there is a defect in the gene for phenylalanine hydroxylase (PAH), which is responsible for converting the amino acid phenylalanine to tyrosine (5). Organic Acids Test The Organic Acid Test is a comprehensive assessment for a wide variety of biomarkers related to yeast (candida) and bacteria toxicity – specifically clostridia bacteria. C.difficile . The most commonly measured organic acids related to impaired fat metabolism are: Possible nutrition-related reasons for poor fatty acid metabolism include carnitine and/or riboflavin deficiency or increased need for these nutrients due to genetic variants. It gives clues if we have a blockage, nutritional insufficiencies, and/or bacterial overgrowth. What is the organic acid test or OAT? Through organic acid testing, we can detect possible nutrient deficiencies, gut dysbiosis, and other imbalances in metabolism. Organic acids that can indicate possible vitamin B deficiencies when out of range include: However, many of these markers have other factors that can increase or decrease their levels, so proper test prep and interpretation is important. Tumors of the adrenal gland called pheochromacytomas can cause the overproduction of the neurotransmitter epinephrine, resulting in marked increases in its metabolite, vanillylmandelic acid (VMA). I hope that many practitioners start using OAT tests as they are very helpful. Some of these bacterial byproducts from the intestine enter the blood stream and may alter the metabolism of neurotransmitters such as dopamine. A portion of these acids is absorbed and excreted into the urine, providing insight into diet and gut health. When you fast or consume a very low-carbohydrate diet, the body naturally produces ketones to be used for energy instead. "After identifying a low serotonin level on an Organic Acid Test (a hallmark functional medicine test), A severely depressed and suicidal man began taking 100mg of 5htp twice a day (5htp is the direct precursor to serotonin). It also evaluates oxalate toxicity, as well as mitochondria function, and various markers for … The cause of these high levels could include oral antibiotic use, high sugar diets, immune deficiencies, acquired infections, as well as genetic factors.Our Organic Acids Test also includes markers for vitamin and mineral levels, oxidative stress, neurotransmitter levels, and is the only OAT to include markers for oxalates, which are highly correlated with many chronic illnesses.If abnormalities are detected using the OAT, treatments can include supplements, such as vitamins and antioxidants, or dietary modification. Metabolism is the sum of chemical reactions in living beings by which the body builds new molecules and breaks down molecules to eliminate waste products and produce energy. The number of organic acids found in urine is enormous. By testing for organic acid concentrations in the urine, can indicate a compromise of a major metabolic pathway that can … Organic acidemias are disorders of intermediary metabolism that lead to the accumulation of toxic compounds that derange multiple intracellular biochemical pathways including glucose catabolism (glycolysis), glucose synthesis (gluconeogenesis), amino acid and ammonia metabolism, purine and pyrimidine metabolism, and fat metabolism. Mitochondrial dysfunction (when mitochondria do not produce energy at their optimal rate) can be caused by genetic disorders, inadequate nutrition, inflammation, environmental toxins, medications, viral infections, and DNA damage (65, 66, 67, 68). If you’re deficient in vitamin B12, methylmalonyl CoA cannot be converted to succinyl CoA. Yay functional nutrition! You collect your first-morning urine, freeze overnight and then post the sample back to the lab in the USA with the provided reply paid packaging. Organic Acids Test (OAT) URINE SAMPLE The Organic Acids Test (OAT) offers a comprehensive metabolic snapshot of a patient’s overall health with over 70 markers. Infection Profile (OAT+MYCO-TOX) - Urine Test toxic non-metal chemicals & ENVIRONMENTAL POLLUTANTS. I have had a great deal of success in treating complicated PMS cases that didn't respond to typical female hormone balancing therapies. Thanks for sharing such detailed information. They are not diagnostic of neurotransmitter levels in the brain or spinal cord. Listen to The Lab Report podca… For cars, the exhaust fumes that come out of the tailpipe are a byproduct of fuel combustion, and the composition can tell us how efficiently the engine burns fuel. These metabolites can give clues about the efficiency (or lack of) of your internal cellular processes, as well as gut microbes. These disorders include, but are not limited to: hyperactivity, movement disorders, and immune function. I’d be lying if I said it wasn’t one of my favourite tests to interpret. Im in Dallas but my results are all scanned and easily emailed. diagnostic of any particular overgrowth but can help guide further testing decisions. The Microbial Organic Acids Test (MOAT) is ideal for follow-up to the OAT and is often recommended by practitioners looking for a specific abnormality, to monitor certain microbial imbalances, or to assess treatment efficacy. Organic Acids Test – clinically significant areas Yeast & Bacteria. A skilled practitioner can look at the bigger picture to find patterns that point to possible root causes. More than 50 phenotypically different organic acidemias are now known since the oldest known disease, isovaleric acidemia, was described in 1966. 1. One of the most important uses of the organic acids test is as an indicator of dysbiosis, an abnormal overgrowth of yeast and bacteria in the intestinal tract. In short, I don’t recommend this as your first go-to test for gut health—or any health—diagnosis. By measuring the levels of organic acids created during these processes, we can get insights into how well the liver and kidney’s detoxification processes are working. Performing an organic acid test is relatively easy. In order to communicate between neurons, the nervous system produces chemical messengers called neurotransmitters. Many organic acidemias are associated with slight to marked increases in plasma ammonia. More human research is needed to better understand the links between gut microbiota, diet, urinary organic acids, and various medical conditions. Since utilizing the OAT, it has provided me with a variety of information to determine the underlying cause of female related issues. I like to spread awareness on this test because I see so many people struggling with vague symptoms. Learn More. Many other non-genetic factors can also alter human metabolism. Some of the nutritional markers tested as a part of OAT may point to valid nutrient deficiencies, mainly: methylmalonic acid, pantothenic acid, methylcitric acid, and uracil/thymine. Histamine (International) $ 52.00. that includes more than 30 different OAs. Microbial Organic Acids Test (MOAT) MycoTOX Profile (Mold Exposure) Organic Acids Test (OAT) Porphyrins Profile . Organic acid testing (OAT) has become very popular amongst functional medicine doctors and dietitians. They also offer a Microbial Organic Acids Test (MOAT) that can be used as a follow-up to the OAT for patients who have been treated for dysbiosis. ENVIRO-TOX Panel - Urine Test metabolic, nutritional, and neurological disorders. that can be used as a follow-up to the OAT for patients who have been treated for dysbiosis. Metabolism is the sum of chemical reactions in living beings by which the body builds new molecules and breaks down molecules to eliminate waste products and produce energy. The OAT can be a complicated test with many markers indicating a variety of potential problems. Who Might Benefit from Organic Acid Testing? Our own membership site, The Functional Nutrition Library, currently includes in-depth notes on interpreting the neurotransmitter-related organic acids, and additional notes will be added in the future. Upon treatment, patients and practitioners have reported significant improvement such as decreased fatigue, regular bowel function, increased energy and alertness, increased concentration, improved verbal skills, less hyperactivity, and decreased abdominal pain. AD(H)D Panel. The sample is then frozen and shipped to the laboratory, where organic acids are measured from the urine sample using liquid or gas chromatography-mass spectrometry (131). Depending on which OAs are being measured, the instructions might require you to avoid certain foods and supplements for a couple of days leading up to the test as well. We use the OAT from Great Plains Laboratory because we love the oxalate markers which no other OAT test seems to offer. COMBO & TEST PANELS KITS (Some are Available in the USA only*) Autism Panel. Clinical presentations of organic acidemias vary widely and may include failure to thrive, intellectual development disorders, hypo- or hyperglycemia, encephalopathy, lethargy, hyperactivity, seizures, dermatitis, dysmorphic facial features, microcephaly, macrocephaly, anemia and/or immune deficiency with frequent infections, ketosis and/or lactic acidosis, hearing, speech, or visual impairment, peripheral neuropathy, sudden cardiorespiratory arrest, nausea and coma. The accumulation of an organic acid in cells and fluids (plasma, cerebrospinal fluid, or urine) leads to a disease called organic acidemia or organic aciduria. It's a useful test to identify key issues in depression, anxiety and ASD. species, including. At certain levels, organic acids in urine may be indicators of toxicity or “markers” of the function of metabolic pathways. In others, such as medium chain acyl dehydrogenase deficiency, a child might appear completely normal until a potentially fatal episode of cardiorespiratory arrest. I haven’t heard of this testing before so I really appreciate the thorough insight! An organic acid is any compound that generates protons at the prevailing pH of human blood. Dr. Jenny … I need to find someone who take medicare to evaluate my results. The OAT Panel complements the … For healthcare practitioners interested in learning more about organic acid testing, Great Plains Laboratory regularly holds in-person trainings around the world. Abnormally high levels of these microorganisms can cause or worsen behavior disorders, hyperactivity, movement disorders, fatigue and immune function. Organic acid testing is still mostly used for the diagnosis of these disorders, but the science has progressed, and now we can use OAT to evaluate overall metabolic health as well. Organic acids are a broad class of compounds formed during fundamental metabolic processes in the body. Price varies for international OAT kits – please contact our laboratory for more information on international kits. Organic acid testing is one of the best ways to test for mitochondrial dysfunction, since it measures most of the intermediates in the citric acid cycle (65, 74, 75, 76). Oxidative stress occurs when there is an imbalance between free radicals and antioxidants within the body (89). The Organic Acids Test, commonly called the OAT test is one of my favorite functional medicine tests - this Great Plains Laboratory OAT test review will explain why.. Organic acid testing measures 70+ different markers looking at many aspects of your health, and these types of metabolites cannot be tested with standard pathology tests. Metabolic reactions produce these compounds from the digestion of dietary protein, fat, and carbohydrates. Possible nutrition-related reasons for poor fatty acid metabolism include carnitine and/or riboflavin deficiency or increased need for these nutrients due to genetic variants. It provides an evaluation of intestinal yeast and bacteria. This profile assesses major metabolic areas that may be compromised by common lifestyle and dietary factors, such as nutrient deficiencies, toxicity, bacterial overgrowth, or medications. An OAT tests a multitude of organic acids that are byproducts of daily cellular metabolism. The resulting organic acids are used by the body to generate cellular energy and provide many of the building blocks necessary for cell function. Some of the markers that I find valuable for women's health issues are the bacterial and yeast metabolites, oxalates, B vitamins, vitamin C, and pyroglutamic acid. It’s a pee test – Your pee literally takes a trip all the way to the USA and back and then gets analysed in depth for hours – It’s very important pee you know! Your healthcare practitioner can order it for you, but it is not always covered by insurance. The main reasons for abnormal urinary organic acid results include: We’ll review each of these scenarios in detail below. Urinary organic acids related to detoxification and/or liver and kidney function that are commonly measured on OATs include (101): Depending on which organic acid levels are out of range, nutrition and lifestyle interventions may be recommended, including: A practitioner well-versed in functional nutrition can best assist in these recommendations. Organic acids are substances in which carbon and hy… This is why organic acids are rarely tested in blood or serum. Unusually high levels of these microorganisms often cause or increase the severity of behavior disorders. This urine-based test provides a wealth of information about the functioning of various bodily systems and can be used to identify possible nutrient deficiencies, gut dysbiosis, and more. 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